Detoxification treatments evaluated by the Ministry of Science and Innovation

Below is a short summary of the most relevant parts of each report on this detoxification treatment under sedation, evaluated by this body.Our rapid heroin and opiates detoxification treatment, UROD, has been evaluated by the Health Technology Assessment Agency (AETS) of the Carlos III Health Institute, which belongs to the Ministry of Science and Innovation. The reports from the agency confirm 100% success in detoxification of the 962 sample cases that have followed the treatment.

Report I Summary

Instituto de salud Carlos IIIMinisterios de economía y competitividad España

Garcia-Comas L*, Alcaide JF*, Amate JM*, Conde JL*, Legarda JJ**.

The present work contains the evaluation of the effectiveness of the UROD treatment, Ultra Rapid Opiate Detoxification, which aims to precipitate, under heavy sedation, the suppression with naltrexone, and is associated to subsequent rehabilitation in patients who are multiple drug addicts, addicted to opiates, fundamentally heroin and methadone.

Different focuses are presented, which inspire the pharmacological treatments for opiate dependence and the role of detoxification as opposed to maintenance treatments with agonists, point out the meaning of neuroadaptation in addiction treatment. The study covers the development of ultra rapid detoxification treatments, marking the aims and limitations of them.

Results are presented from a sample of 962 cases treated by the Tavad center with the UROD method, being followed up for 9 months, during which time the patients had various possible treatments at their disposal: psychotherapy supervised by Tavad for 1 to 9 months, or other models of psychotherapy outside those of Tavad, in conjunction with pharmacological support from naltrexone for 9 months.

100% retention is achieved in detoxification and 99.9% access the support treatment. After 9 months 58.1% success was recorded out of the total number of patients who finished the detoxification and began the psychopharmacological rehabilitation which the Tavad clinic currently carries out; this figure increases to 90%, proportionally to the length of time in rehabilitation.

(*) AETS. Carlos III Health Institute (Ministry of Science and Innovation). C/Sinesio Delgado, 6 – 28029 Madrid (Spain)

(**) TAVAD – Advanced Addiction Treatments. Avenida Fuentelareina, 8 – 28035 Madrid (Spain) – 902100197

Report II Summary

Garcia-Comas L*, Alcaide JF*, Amate JM*, Conde JL*, Legarda JJ**.

This document is dedicated to discussion about the report on Evaluation of the Effectiveness of the UROD Treatment in association with subsequent rehabilitation in patients addicted to heroin, whose description was published by the Health Technology Assessment Agency. The current title refers to opiates; therefore the discussion shows detoxification of patients addicted to methadone undergoing this treatment.

It was by wish of this agency, and agreed by the company which applied for the study (Tavad), that both documents, Descriptive and Discussion, were presented separately due to their size and the nature of their contents.

The Descriptive Report refers to the processing of information recorded in the databases at Tavad and undertaken by this Agency. As a result it lacks a bibliography, intending to show the figures in their bare state, so that any interested reader can analyse them according to their own criteria.

In this new document analysed figures from the previous report are dicussed. To make reading easier without obliging the reader to use both documents simultaneously and so that this document is comprehensible by itself, the most relevant result tables which help to focus one’s thoughts have been incorporated.

In both cases, the documents are components of a single report, for those who intend to make an exhaustive critical analysis; both documents should be used simultaneously.

(*) AETS. Carlos III Health Institute (Ministry of Science and Innovation). C/Sinesio Delgado,6 – 28029 Madrid (Spain)

(**) TAVAD – Advanced Addiction Treatments. Avenida Fuentelareina, 8 – 28035 Madrid (Spain) – 902100197